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Downregulation of transcription factors by ribonucleic acid interference. A novel approach to extend the multipotency of autologus adult stem cells?

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References

  • Akiyama, H.; Chaboissier, M. C.; Martin, J. F.; Schedl, A.; de Crombrugghe, B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16(21):2813–2828; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Barry, F. P.; Murphy, J. M. Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell Biol. 36(4):568–584; 2004.

    Article  PubMed  CAS  Google Scholar 

  • Bradley, J. A.; Bolton, E. M.; Pedersen, R. A. Stem cell medicine encounters the immune system. Nat. Rev. Immunol. 2(11):859–871; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Capodici, J.; Kariko, K.; Weissman, D. Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J. Immunol. 169(9):5196–5201; 2002.

    PubMed  Google Scholar 

  • Goodell, M. A. Stem-cell “plasticity”: befuddlled by the muddle. Curr. Opin. Hematol. 10(3):208–213; 2003.

    Article  PubMed  Google Scholar 

  • Hedrick, M. H.; Daniels, E. J. The use of adult stem cells in regenerative medicine. Clin. Plast. Surg. 30(4):499–505; 2003.

    Article  PubMed  Google Scholar 

  • Hwang, W. S.; Ryu, Y. J.; Park, J. H., et al. Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 303(5664):1669–1674; 2004.

    Article  PubMed  CAS  Google Scholar 

  • Jiang, Y.; Jahagirdar, B. N.; Reinhardt, R. L., et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418(6893):41–49; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Lanza, R. P.; Cibelli, J. B.; West, M. D. Prospects for the use of nuclear transfer in human transplantation. Nat. Biotechnol. 17(12):1171–1174; 1999.

    Article  PubMed  CAS  Google Scholar 

  • Lian, J. B.; Javed, A.; Zaidi, S. K.; Lengner, C.; Montecino, M.; Van Wijnen, A. J.; Stein, J. L.; Stein, G. S. Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors. Crit. Rev. Eukaryot. Gene Expr. 14(1–2):1–42; 2003.

    Google Scholar 

  • McManus, M. T.; Sharp, P. A. Gene silencing in mammals by small interfering RNAs. Nat. Rev. Genet. 10:737–747; 2002.

    Article  Google Scholar 

  • Milhavet, O.; Gary, D. S.; Mattson, M. P. RNA interference in biology and medicine. Pharmacol. Rev. 55(4):629–648; 2003.

    Article  PubMed  Google Scholar 

  • Nakashima, K.; Zhou, X.; Kunkel, G.; Zhang, Z.; Deng, J. M.; Behringer, R. R.; de Crombrugghe, B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108(1):17–29; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Ng, L. J.; Wheatley, S.; Muscat, G. E., et al. SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse 183(1):108–121; 1997.

    CAS  Google Scholar 

  • Reid, T.; Warren, R.; Kirn, D. Intravascular adenoviral agents in cancer patients: lessons from clinical trials. Cancer Gene Ther. 12:979–986; 2002.

    Article  Google Scholar 

  • Sachinidis, A.; Fleischmann, B. K.; Kolossov, E.; Wartenberg, M.; Sauer, H.; Hescheler, J. Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res. 58(2):278–291; 2003.

    Article  PubMed  CAS  Google Scholar 

  • Schrem, H.; Klempnauer, J.; Borlak, J. Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol. Rev. 54(1):129–158; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Shirasaki, R.; Pfaff, S. L. Transcriptional codes and the control of neuronal identity. Annu. Rev. Neurosci. 25:251–281; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Short, B.; Brouard, N.; Occhiodoro-Scott, T.; Ramakrishnan, A.; Simmons, P. J. Mesenchymal stem cells. Arch. Med. Res. 34(6):565–571; 2003.

    Article  PubMed  CAS  Google Scholar 

  • Verfaillie, C. M. Adult stem cells: assessing the case for pluripotency. Trends Cell Biol. 12(11):502–508; 2002.

    Article  PubMed  CAS  Google Scholar 

  • Wagers, A. J.; Weissman, I. L. Plasticity of adult stem cells. Cell 116(5):639–648; 2004.

    Article  PubMed  CAS  Google Scholar 

  • Weil, D.; Garcon, L.; Harper, M.; Dumenil, D.; Dautry, F.; Kress, M. Targeting the kinesin Eg5 to monitor siRNA transfection in mammalian cells. Biotechniques 33(6):1244–1248; 2002.

    PubMed  CAS  Google Scholar 

  • Wilson, J. A.; Richardson, C. D. Induction of RNA interference using short interfering RNA expression vectors in cell culture and animal systems. Curr. Opin. Mol. Ther. 5(4):389–396; 2003.

    PubMed  CAS  Google Scholar 

  • Zhang, M.; Zhang, X.; Bai, C. X.; Chen, J.; Wei, M. Q. Inhibition of epidermal growth factor receptor expression by RNA interference in A549 cells. Acta Pharmacol. Sin. 25(1):61–67; 2004.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Stem Cell Laboratory Faculty of Dentistry, National University of Singapore, 5 Lower Kent Ridge Road, 119074, Singapore

    Boon C. Heng & Tong Cao

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  1. Boon C. Heng
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  2. Tong Cao
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Correspondence to Tong Cao.

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Heng, B.C., Cao, T. Downregulation of transcription factors by ribonucleic acid interference. A novel approach to extend the multipotency of autologus adult stem cells?. In Vitro Cell.Dev.Biol.-Animal 40, 131–132 (2004). https://doi.org/10.1290/1543-706X(2004)40<131:DOTFBR>2.0.CO;2

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  • DOI: https://doi.org/10.1290/1543-706X(2004)40<131:DOTFBR>2.0.CO;2

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